The PI
Magazine Bookstore is
proud to offer investigators Forensic DNA Typing:Biology & Technology
behind STR Markers by John
M. Butler.
Features:
• Provides a comprehensive look at the biology, technology, and applications
of DNA typing
• Focuses on the major molecular biological
technique currently being used throughout the world
• Uses
a wide array of illustrations and examples to make the material
easy to understand
• Progresses
from basic introductory information to cutting-edge research
• Designed for forensic scientists,
law enforcement and legal professionals, and students in
related fields
• Provides DNA analysts with all the reported
alleles for the 13 CODIS STR loci, including sizes and sequences
• Includes
the DNA Advisory Board Quality Assurance Standards
• Reviews DNA testing performed in
high-profile cases
Description:
Forensic DNA Typing focuses on the biology and technology behind
short tandem repeat (STR) markers and the most common forensic
DNA analysis method used today. This comprehensive handbook
will help forensic scientists gain a better understanding of
STRs and the procedures needed to properly analyze them, while
helping professionals in the law enforcement and legal communities
comprehend the complexities of DNA profiling. It will also
help laboratories meet the training requirements in the new
DNA Advisory Board Quality Assurance Standards.
The first few
chapters of Forensic DNA Typing provide a thorough introduction
to the topic for readers who might be less familiar with DNA,
while providing a useful review for more advanced readers.
It goes on to cover new genetic markers and information on
rapidly changing technologies to help professionals make accurate
identifications through DNA typing. Detailed illustrations
and examples are used throughout. The book concludes with reviews
of the DNA testing performed in high-profile cases such as
the O.J. Simpson trial, the President Clinton-Monica Lewinsky
affair, the Tomb of the Unknown Soldier, the Thomas Jefferson-Sally
Hemings family controversy, and others.
John Butler has been
involved in the validation of the short tandem repeat markers
that form the basis of the FBI's nationwide DNA database, CODIS,
and in the development of new and innovative technologies. His
talent for explaining complex information is apparent in the
clear organization, illustrations, and straightforward language
of this text. Forensic DNA Typing has already established itself
as the standard reference in the field.
Key Benefits:
• Chapters cover the topic
from introductory level right up to "cutting edge" research
• Forensic
scientists learn about the new methods and technologies required
by STR typing
• DNA
laboratories find out how to meet the training requirements
of the DNA Advisory Board Quality Assurance Standards (listed
in Appendix III)
• Lawyers
and law enforcement professionals understand the science
behind the techniques
• All readers
can use the information listed on suppliers of DNA analysis
equipment, products and services
Contents:
Foreword
Introduction
Acknowledgements
Overview and History of DNA Typing
Biology
DNA Biology Review
Sample Collection and Preparation (DNA Extraction and Quantification)
The Polymerase Chain Reaction (DNA Amplification)
Commonly Used Short Tandem Repeat Markers
Biology of STRs: Stutter Products, Non-Template Addition, Microvariants, Null
Alleles, and Mutation Rates
Forensic Issues: Degraded DNA, PCR Inhibition, Contamination, and Mixed Samples
Additional DNA Markers: Amelogenin, Y-Chromosome STRs, mtDNA, SNPs, Alu Repeats
Technology
DNA Separation Methods: Slab-Gel and Capillary Electrophoresis
DNA Detection Methods: Fluorescent Dyes and Silver Staining
The ABI Prism 310 Genetic Analyzer
The Hitachi FMBIO II Fluorescence Imaging System
STR Genotyping Issues
Laboratory Validation
New Technologies and Automation
Combined DNA Index System (CODIS) and the Use of DNA Database
Biology, Technology and Genetics
DNA Testing in High-Profile Cases
Appendix I: Reported STR Alleles: Sizes and Sequences
Appendix II: CEPH Family Study
Appendix III: DNA Advisory Board Quality Assurance Standards
Appendix IV: Suppliers of DNA Analysis Equipment, Products, or Services
Index
Hardcover
322 pages
9 7/16" X 7 11/16"
retail $79.95
Our Price $63.95
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